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KMID : 0370019980120000121
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Chung-Ang Journal of Pharmacal Sciences
1998 Volume.12 No. 0 p.121 ~ p.126
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Inducible viral gene expression in HCMV mediated by tetracycline inducer
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Abstract
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Recombinant viruses containing the US11 gene under the control of the tet O-modified US11 promoter were isolated ; DNA blot analysis attested to the fidelity of the recombination Western blot experiment using polyclonal antisera of US11 gene product indicated that US11 gene expression of the recombinant virus was induced in the infected tTA expressing cell lines by the presence of tetracycline. This tetracycline-dependent inducible gene expression system has potential applications to study the biological roles of HCMV genes.
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